Irreproducibility Dogs New Reprogramming Method

first_imgTOKYO—Since January, scientists around the world have unsuccessfully attempted to reproduce a surprising stem cell finding that claimed simply stressing adult cells could turn them into powerful stem cells that resemble those found in early embryos. Now, ScienceInsider has learned that some of the labs involved in producing the two papers describing the work had not attempted to reproduce the technique before the papers were published. Only two of the labs involved in the papers say they have been able to generate so-called STAP cells.The controversy emerged about 2 months ago, when stem cell scientist Haruko Obokata suddenly became a media sensation in Japan. The 30-year-old was widely celebrated when she and colleagues published two papers in Nature describing a new and surprisingly simple way of creating stem cells, which the researchers dubbed stimulus-triggered acquisition of pluripotency (STAP) cells.Now, Obokata is still in the spotlight, but the script has changed. Allegations that the papers contain images recycled from Obokata’s Ph.D. thesis, among other problems, have fed doubts about the claims. And as the scrutiny has grown, several of the collaborating researchers have confirmed that they have not yet produced STAP cells either.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)It would not be unusual for the lead author to perform most of the work for the papers, says Martin Pera, a stem cell scientist at University of Melbourne in Australia. But given how revolutionary—and simple—the technique was supposed to be, he says, “the uncertainty concerning reproducibility is puzzling.”Earlier methods for deriving pluripotent stem cells, the all-purpose cells valued for their possible role in regenerative medicine, required extracting them from embryos or forcing adult cells to overexpress certain genes. But in an article and a letter online in Nature on 29 January, Obokata and her colleagues at the RIKEN Center for Developmental Biology (RIKEN CDB) in Kobe, Japan, and at other institutions in Japan and the United States described an astonishingly simple alternative. All it took to make pluripotent stem cells, they reported, was briefly bathing blood cells from newborn mice in a mildly acidic solution and then tweaking the culture conditions.Within days, questions about images in the two papers started appearing on blogs and the PubPeer website. RIKEN CDB’s Tokyo-based parent organization, RIKEN, launched an investigation on 13 February. New allegations about these and previous Obokata papers continued to emerge.On 14 March, the investigative committee chair and other RIKEN officials announced the interim results at a standing-room-only press conference in Tokyo. RIKEN president and Nobel laureate Ryoji Noyori opened the event with a deep bow. “I apologize for the great trouble and concerns caused to so many in society by the STAP papers published in Nature by RIKEN researchers,” he said.The investigating committee concluded that there had been “inappropriate handling of data” for two of the items under investigation, but these were “not judged to constitute research misconduct,” according to a RIKEN press release. But the officials emphasized that they are relying on the scientific community to ultimately decide whether STAP cells can be derived following the method Obokata and her colleagues described. “The mission of the investigating committee is to determine whether or not there has been misconduct; whether STAP cells exist is something for the scientific community to determine,” said committee chair Shunsuke Ishii, a RIKEN molecular geneticist, at the press conference, which lasted a marathon 4 hours. He added that to the best of their knowledge, no outside group has reported success in generating STAP cells.Among the authors, only Charles Vacanti, an anesthesiologist and tissue engineering specialist based at Brigham and Women’s Hospital in Boston, says his lab can make STAP cells. Obokata worked under Vacanti for several years, starting in 2008, and developed the STAP technique based on some of his earlier work. Another co-author, Teruhiko Wakayama, who moved in 2012 from RIKEN CDB to the University of Yamanashi, Kofu, confirmed in an e-mail to Science that he had made STAP cells while working alongside Obokata at RIKEN but has not been able to reproduce them at his new lab. Two other co-authors, Hitoshi Niwa and Yoshiki Sasai of RIKEN CDB, had not attempted to generate the cells independently in their labs before the papers were published. “I’m confused,” says Hans Schöler, a stem cell researcher at the Max Planck Institute for Molecular Biomedicine in Münster, Germany. Niwa and Sasai are highly regarded scientists, he says, and their names as authors lent the papers substantial credibility. RIKEN CDB Director Masatoshi Takeichi said at the press conference that Niwa’s lab is now working to reproduce the results independently of Obokata.Wakayama’s own doubts have grown. A stem cell biologist known for work cloning mice, he says he was brought onto the team to produce the chimeric mice described in the paper. He used cells provided by Obokata, he says. “I want to believe” in STAP cells, Wakayama says. However, he says, the photos that convinced him that the cells were real are those now believed to have come from a completely different experiment reported in Obokata’s doctoral dissertation. “I do not think this is a simple mistake,” Wakayama says, adding, “I no longer know to what extent Obokata’s story is the truth.” On 10 March, Wakayama called for the papers to be retracted, at least temporarily, until errors are corrected and results confirmed.  At the press conference, Ishii said that the investigating committee had resolved two of six specific issues in the papers. One problematic image is an artifact of image compression and “not falsification or improper conduct,” the interim report states. But the claims that figures in the article were used in Obokata’s thesis seem to be on target. Obokata and one of her co-authors told the committee that these figures were used by mistake. Ishii emphasized that this issue is still under investigation and any judgments about misconduct will come after further deliberation.In a written statement released to the press, Obokata, Niwa, and Sasai apologized for the confusion resulting from the uncertainties and inaccuracies in the papers and wrote: “We are contacting other co-authors regarding the possibility of retracting these papers.”Vacanti is reluctant. “In the absence of compelling evidence that the data presented is incorrect, I do not believe that the manuscripts should be retracted,” he wrote in a statement.A Nature spokesperson told Science by e-mail that the journal’s own investigation “is still in progress.” Not all the authors would necessarily have to agree to a retraction, the spokesperson wrote.The Nature papers are not the only Obokata publications under fire. Allegations surfaced last week that large portions of one chapter of her doctoral thesis, submitted to Waseda University in 2011, appear to have been copied from a National Institutes of Health website and that footnotes to other chapters were copied and pasted from other publications. Local media have reported that Obokata said she intends to withdraw the dissertation. A Waseda public relations official confirmed that a faculty member had received such an e-mail but said that the university, which is investigating, has not received a formal request from Obokata. If the thesis is retracted, Obokata will lose her doctoral degree.The glare of the spotlight is not always comfortable.*Correction, 19 March, 10:12 a.m.: This item has been corrected. An earlier version incorrectly stated that six labs were involved in the papers, but several more contributed to the published work.last_img read more

Lawsuit sheds light on controversial heart stem cell papers

first_imgA lawsuit filed earlier this week by two researchers involved in an investigation into possible scientific misconduct offers the first indication of just what was amiss in two papers that have been called into question. The complaint filed in a federal district court acknowledges that there are fictitious data points in a now-retracted 2012 paper that appeared in the journal Circulation, and altered figures in a much-publicized 2011 paper in The Lancet that is now under scrutiny. But it blames those problems on a third researcher—raising questions about who bears final responsibility for possible misconduct.The lawsuit was filed by cardiac stem cell scientist Piero Anversa of Brigham and Women’s Hospital in Boston, an affiliate of Harvard Medical School, and Annarosa Leri, a Harvard associate professor in his lab. The pair is suing Harvard and Brigham, claiming that investigations launched by the institutions have wrongfully damaged their careers. In particular, they allege that news of the investigations, which came to light this past April, cost them millions of dollars by derailing a deal to sell their stem cell company, Autologous/Progenital, and took them out of the running for lucrative faculty positions. They are asking for unspecified compensation. The complaint alleges that Anversa and Leri were unaware of any misconduct and lays blame on Jan Kajstura, the first author on the retracted paper and a former member of a lab headed by Anversa.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In the case of the Circulation paper, which reported a surprisingly high turnover rate for muscle cells in the adult heart, Leri and Anversa say that Kajstura apparently altered, without their knowledge, data from mass spectrometry experiments performed at Lawrence Livermore National Laboratory (LLNL) in California. (A researcher at LLNL contacted Anversa’s lab after noticing there were 20 additional data points in the Circulation paper than he had sent in a spreadsheet, they say.)They further argue that Kajstura and another unnamed scientist under his supervision were responsible for the now-questioned figures that ended up in the Lancet paper, which reported on the results of a phase I clinical trial involving a stem cell treatment for heart failure. The figures apparently don’t match other clinical trial paperwork characterizing the stem cells that were used. (Anversa and Leri say they are willing to correct that paper, but claim they are waiting for approval from the institutional review board that oversaw the study.) The complaint also notes that 15 other papers were later added to the investigation.Kajstura could not be reached for comment. And it is not known whether he is implicated in the investigations under way at Harvard and Brigham, because the institutions have not released any findings so far and have declined to comment on the inquiries.The lawsuit raises broader questions about who bears responsibility for misconduct in large biomedical research laboratories involving many researchers, who often work in relative independence. “In the abstract, I think everyone agrees that a principle investigator has to take responsibility for whatever goes on in his or her lab,” says Ferric Fang, a microbiologist at the University of Washington, Seattle, who has published several analyses of retractions, misconduct, and the scientific enterprise. But the community is often forgiving when misconduct slips past a principal investigator, he says. Several high-profile scientists have survived damage to their careers by being forthright about wrongdoing in their labs.In this case, the retraction and investigation occurred even as other outside observers were raising questions about the science and integrity of both the lab and Anversa specifically, he notes, including recent criticism of the lab culture published on Retraction Watch by an anonymous former trainee. As a result, he says, damage to the researchers’ careers may not stem entirely from actions by the institutions. “Aside from the specifics of this particular case,” he says, “I think it would be a very dangerous precedent to hold institutions culpable for doing due diligence in investigating allegations of problematic data,” he says.In the complaint, Anversa and Leri make specific and very strong accusations about the mishandling of the investigation and possible conflicts of interest. They are suing both Elizabeth Nabel, president of Brigham, and Gretchen Brodnicki, Harvard’s dean for faculty and research integrity, who launched the initial inquiry into the lab and called for the retraction of the two papers.Nabel, who is also a scientific adviser at Moderna Therapeutics Inc., should have recused herself from the investigation, Anversa and Leri argue, because Moderna is developing a treatment that competes with therapies developed in their lab. They also say that she is a financial stakeholder at Moderna and that she inappropriately disclosed information about the investigation and personally maligned Anversa and Leri.The claims of a confidentiality breach and conflict of interest, if they prove true, “are serious, and are not off-the-wall,” says Paul Rothstein, a professor of torts, evidence, and civil litigation at Georgetown University Law Center in Washington, D.C. They could “give a court some serious issues to deal with and think about.”As for the damages over lost employment opportunities and the derailed business deal, Rothstein points out that courts require a high degree of proof that the defendants are directly responsible—and that the business deals would have been a certainty if not for the defendants’ actions. That is often hard to demonstrate, Rothstein says, suggesting Anversa and Leri may face obstacles in making their case.last_img read more

Virat Kohli ignores Harbhajan Singh’s pitch jibe

first_imgIndia’s Test skipper Virat Kohli on Tuesday said that the players believed in their skills rather than conditions and or atmosphere. (Proud of my brothers, tweets Kohli after India whitewash New Zealand)India mauled New Zealand by 321 runs in the third and final Test at the Holkar Cricket Stadium here.Completing a 3-0 clean sweep in the series, India have now stamped their authority and clinched the No. 1 International Cricket Council (ICC) Test ranking from Pakistan. They had already bagged the top spot after winning the second Test at Kolkata. (Kohli gets ICC Test Championship mace, calls it ‘special’)The formality was completed on Tuesday evening when ‘ICC Hall of Fame’ Sunil Gavaskar presented the Test championship mace to Virat Kohli at after-match presentation ceremony. (Captain Kohli surpasses Pataudi, Gavaskar’s record)”That’s the right step we have taken. We believe in our skill and not believe in creating conditions or atmosphere which might suit us partially. We wanted to express ourselves. We finished two games in four days and that gives us a lot of confidence,” said Kohli after the match. (Ashwin’s stats are a topic of discussion in the dressing room; Virat Kohli)KOHLI’s MANTRA – PLAY POSITIVE CRICKETKohli said that the team tried to play the second innings with more intent so that bowlers can express themselves. (Scorecard | Match Highlights)”We try to play positive cricket in the second innings and try to give the bowlers as much enough overs to bowl, and secondly enough runs to keep expressing themselves and not set defensive fields,” Kohli said.advertisement”This was a situation where we batted them out of the game. We could express ourselves best and give our bowlers time to bowl out the opposition. The last two Tests played out nicely for us and that’s why we could finish both the games in four days,” he added.Star off-spinner Ravichandran Ashwin once again single-handedly triggered another batting collapse of the Kiwis, to return with career-best figures of 7/59 in the visitors’ second innings, bundling them out for a paltry 153 in response to the mammoth target of 475.The 27-year-old Delhi batsman also spoke about recent tweet of Harbhajan Singh that if they had helpful pitches earlier in his career, he and Anil Kumble would have grabbed many more wickets.”Even if it is a turning pitch, you have to bowl well. Spin is just not something to happen only off the pitch. It depends on how many revs (revolutions) you give to the ball and the use of the shoulder. When we lost to New Zealand in the World Cup, I quite clearly remember, suddenly their spinners were quality bowlers and we were found out! I don’t see anyone talking about it now,” Kohli said.”The same (New Zealand) spinners had played (in this series). Why did not they pick up wickets? It’s as simple as that. Our fast bowlers (also) picked up wickets everywhere. Give a guy a cement track to bat on. He should have a mindset to do so. It’s as simple as that. That’s all I am going to sum up,” he added.last_img read more

Pro-Kabaddi player wife kills self; alleges harassment, dowry

first_imgNew Delhi, Oct 18 (PTI) Wife of a national-level kabaddi player, who also represents a franchise in the Pro-Kabaddi League, allegedly committed suicide in Delhis Nangloi area accusing her husband and in-laws of “mental and physical harassment” in her suicide note.Police said 27-year-old Lalitas body was found hanging at her home in Nangloi last evening, police said.She had married Rohit Kumar, who represents Bengaluru Bulls in the Pro-Kabaddi League, on March 16, a senior police officer said.It was a love marriage and her second marriage. Her father-in-law used to taunt her about getting married for the second time, police said.In a long video message and a suicide note, Lalita has accused her in-laws and husband of “mental and physical harassment” over several issues, including dowry and her past.”She has made a number of allegations in her video message and her note. She alleged that her in-laws and Rohit used to mentally and physically harass her. They would even make dowry demands,” said a senior police officer.She alleged that on October 15, Rohit told her that if she goes away from his life, he would be very happy. He dropped her halfway to her home and left, she alleged.She also alleged that Rohit used to travel outside Delhi frequently leaving her alone which was upsetting for her.A senior police officer said her parents gave their statement in front of the SDM and alleged that their daughter was harassed by her husband and in-laws.”A case was registered under sections 498A (Husband or relative of husband of a woman subjecting her to cruelty) and 304(B) (dowry death),” said the officer.advertisementRohits family lives in Delhis Kanjhawla area but they are said to be absconding and since the incident and police are on the lookout for them.Lalitas first marriage had also fallen apart because of dowry demands and she had to face similar situation in her second marriage too, which was depressing for her, said the senior police officer.Lalita was studying at a college where Rohit used to come for swimming practice and that is how they met and got into a relationship, said a senior police officer.The 26-year-old kabaddi player got into the Naval Forces in 2009 through the sports quota and was posted in Mumbai.Police are currently on the lookout for him so that they can question him in the matter. PTI SLB TIRlast_img read more

Roger Federer a source of inspiration for chess legend Viswanathan Anand

first_imgHe may be a former world no.1 and winner of multiple titles but chess legend Viswanathan Anand says he felt uneasy when people took out ‘former’ and refered to him as ‘world champion’, not too long ago.But that was until he won the World rapid chess title again last December. “I am a current champion at something now, so it’s ok,” Anand says.Burden of a thick CV can be unnerving for a top athlete when championship success deserts you.It holds true for champions in all sport. When the going gets tough, they often feed of each other for inspiration.Anand’s rapid title success took some time coming; his first after losing the classical championship to Magnus Carlsen in 2013. Even in a game like chess, when you are on the wrong side of 40, the retirement question pops up frequently.But Anand isn’t showing any signs of slowing down any time soon and revealed that he derived inspiration from Swiss tennis ace Roger Federer and his remarkable resurgence at the age of 36. Like Anand himself, Federer continues to win Grand Slam tournaments by beat opponents who are much younger to him.”Yes. When you see someone else do it, you feel more relaxed about trying it yourself. I am convinced the reason you stop playing well is not age but because you have stopped adapting. So when someone is doing well you try to learn from that. You do look for examples from other sports that can take you to the right direction,” Anand told India Today.advertisement”Having said that I think it’s the two titles he won last year (Australian Open and Wimbledon, 2017) that impressed me more than the fact that he didn’t win (Wimbledon) this year. I think sometimes when people do remarkable things you forget that the unremarkable thing is more normal. It’s more normal that he didn’t win this year than if he would have won again,” Anand said in praise of Federer.Although chess and tennis are very different sports, Anand draws parallels amongst champions who find the key to success while defying the age factor.”I think stylistically the way Federer has adapted is the key. For tennis, it is the same as for chess players. In chess it is very hard to do something that is stylistically different. It’s difficult for a technical player to be a tactical one and vice versa.”So being able to change his style is something I find impressive. And he has done that quite well; which is the reason he is competing against people who are much younger,” Anand said.last_img read more

No stopping Messi and Barca in La Liga

first_imgPrimera División No stopping Barca as Messi & Co. leave Atleti, Valencia & Madrid in their wake Ben Hayward Last updated 1 year ago 06:26 1/22/18 FacebookTwitterRedditcopy Comments(20) Lionel Messi Barcelona Getty Images Primera División Lionel Messi Real Betis v Barcelona Real Betis Barcelona Opinion The Blaugrana extended their commanding lead at the top of the Primera Division with a 5-0 win at Betis and surely nobody can catch up now There was a glimmer of hope for Barcelona’s rivals. When Ernesto Valverde’s side lost to Espanyol in the Copa del Rey on Wednesday night, it perhaps proved that the Liga leaders are beatable after all. A trip to in-form Betis on Sunday looked likely to be a tough test.Betis had recently beaten city rivals Sevilla 5-3 in the derby at the Sanchez Pizjuan and, after Messi missed a penalty in the 1-0 loss at Espanyol, their coach Quique Setien said: “Let’s see if that guy who decides so many matches comes here thinking more about the Copa and gives us a chance.”Alas, that was not to be for Betis nor for Setien, whose other pre-match quote on the Argentine turned out to be closer to the truth. “Nobody can stop him,” he said. “Even though we all know he is the most decisive player…” Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player The 30-year-old scored twice in a one-sided second half, Barca cleverly exploiting a risky high defensive line from the home side as all five strikes came after the interval.The first of those was for Ivan Rakitic, the Croatian midfielder racing through to slot home his fifth goal against Betis in La Liga. As a former Sevilla player, it clearly meant a lot.Suarez set that one up and the former Liverpool striker scored two himself to make it seven matches in a row in La Liga. So off form earlier this season, he has now become only the second Uruguayan to score 100 times in La Liga (after Diego Forlan) and is clearly back to his brilliant best for Barca.Messi also netted a double and made it to 25 goals for the 10th season in a row, a record that is likely to be levelled soon by Real Madrid’s Cristiano Ronaldo (on 18 this term).The Argentine’s assist for Suarez means he has set up goals for five successive games in La Liga for the first time in his career. And in the Primera Division it is now 54 points for Barca after 20 fixtures, with 17 wins and three draws and a goal difference of +48.Rakitic BetisLionel Messi Javi Garcia Barcelona Real BetisWherever you look, it is hugely impressive and it is difficult to see any side stopping Barca now. Atletico, in second, are 11 points behind after their draw with Girona on Saturday, while Valencia are 14 back and Real Madrid 19 adrift.Zinedine Zidane’s side still have a game in hand, but it would take a miracle now for Los Blancos to catch their fierce rivals in La Liga. Atletico and Valencia are also well adrift and surely now it is a question of how many points Barca will win by, not whether they will win it?Attentions now turn to the Copa del Rey for Barca, as they seek to overturn the 1-0 deficit against Espanyol at Camp Nou this week. But with Messi and Suarez in such fine fettle and Valverde’s men conceding so little at the back, it should not be too much of a problem.Indeed, if any team are to stop Messi and Barca this season, it is certainly going to take something special.last_img read more

Report Navig8 Adds More Ships to Orderbook in China

first_imgzoom UK-based shipping company Navig8 Group has increased its orderbook with up to six more vessels, data provided by Asiasis shows.The company reportedly exercised options for four tankers, each featuring 50,000 dwt, and two more Aframaxes.Although financial details related to the orders were not disclosed, Asiasis listed 2019 as the year of delivery for the new ships.The additional units would be constructed by China’s shipbuilding major New Times Shipbuilding.On its website, Navig8 Group listed eight MR tankers which are currently on order at the shipyard. The data indicated that the units would join their owner one per month starting from April 2019.World Maritime News Stafflast_img read more

Rostock to Supply First AIDA Ships with Shore Power in 2020

first_imgzoomImage Courtesy: AIDA Cruises German cruise line AIDA Cruises has signed a Declaration of Intend with the state of Mecklenburg-Western Pomerania, the Hanseatic and University City of Rostock and Rostock Port to jointly promote environmentally friendly and sustainable cruise shipping in Rostock.The aim of the agreement is, analogous to Hamburg and Kiel, to build a shore power plant for cruise ships in the port of Rostock.Already in 2020, the first ships of AIDA Cruises should be supplied with shore power while docking in Rostock-Warnemünde.Therefore AIDA Cruises will fully equip its ships that regularly call Rostock-Warnemünde with a shore power connection.“We are signing a joint declaration so that in future cruise ships can be supplied with shoreside power at the Port of Rostock. I am convinced that this is a good step and it is an important contribution towards making cruise tourism more sustainable,” Manuela Schwesig, Prime Minister of Mecklenburg-Western Pomerania, said.“With our Green Cruising strategy, we are investing billions of euros in a future-proof cruise market – both in the area of sustainable propulsion technologies like the use of LNG or shoreside power, as well as in environmental management on board,” Felix Eichhorn, AIDA President, added.last_img read more

Les plaques dimmatriculation de Démocratie 250 sont maintenant en vente

first_imgLa Nouvelle-Écosse a ouvert la voie à la démocratie parlementaire au Canada, et elle diffuse maintenant son message sur la route, littéralement. Des plaques d’immatriculation commémoratives en l’honneur du 250e anniversaire du premier gouvernement représentatif au Canada, qui sera célébré l’année prochaine, sont maintenant en vente aux centres Access Nova Scotia à l’échelle de la province. Ces plaques bilingues sont le fruit d’un effort de collaboration entre Démocratie 250 et Services Nouvelle-Écosse et Relations avec les municipalités. Elles affichent le logo de Démocratie 250 et invitent les Néo-Écossais à célébrer cette fière première pour la province. « Les plaques commémoratives sont une façon pour les Néo-Écossais de démontrer leur fierté envers leur province et de célébrer le rôle pionnier de la Nouvelle-Écosse dans la formation de la démocratie parlementaire dans notre pays, » a dit l’un des co-présidents de Démocratie 250, le Dr John Hamm. « Les plaques constituent une façon réelle et économique pour les Néo-Écossais de démontrer qu’ils croient dans les principes de la démocratie et des droits et libertés qu’elle offre, » a dit Russell MacLellan, également co-président de Démocratie 250. Les plaques sont disponibles au coût de 11,40 $ (taxe incluse) dans tous les centres Access Nova Scotia, en composant le 1-800-898-7668 ou en ligne à l’adresse suivante : www.democratie250.ca/boutique.html . Pour obtenir plus d’information sur Démocratie 250, consultez le site Web www.democratie250.ca .last_img read more

New Trailhead Building Announced at Thomas Raddall Provincial Park

first_imgHikers have a focal point to explore and better understand the trails at Thomas Raddall Provincial Park in Port Joli, Queens Co. The Trailhead building at the park was officially opened by Natural Resources Minister David Morse today, July 12. “The Trailhead building and signage will provide an informative starting point for those looking to explore the trails and beauty of Thomas Raddall Provincial Park,” said Mr. Morse. “I’d like to thank all those involved in making the Trailhead building a reality.” The building includes a woodstove, power, and projection screen, designed to serve as a starting point for visiting hikers. Interpretive signs provides information on location, difficulty and history of each trail in the park. One sign highlights the significance of the life and writings of Thomas Raddall to the local area. The departments of Tourism, Culture and Heritage and Natural Resources and the Region of Queens Municipality contributed to the effort. The Raddall family were also thanked for its continued participation. Thomas Raddall Provincial Park was opened in 1997, and covers 678 hectares on a coastal peninsula. The park includes a day-use area, 82 overnight camping sites, four group-use sites, and an 11-kilometre trail system. Mr. Morse also announced details of another recent development in Queens County. Seventy-three hectares of land were acquired at Carters and Wobamkek beaches. “The beaches are home to the rare piping plover, and are a local favourite to beachgoers,” said Mr. Morse. “We are happy to announce that the land has been secured.” Staff are developing a long-term management plan, which will outline the objectives for the area.last_img read more

Premier Expresses Sadness Over the Death of Arnie Patterson

first_imgPremier Darrell Dexter expressed sadness today, March 9, over the death of long-time Dartmouth resident Arnie Patterson who died Tuesday after a battle with cancer. “I was lucky to have had the opportunity to work for Arnie at CFDR radio when I graduated from university,” said Premier Dexter. “He was a hard worker, a visionary and indeed a proud Nova Scotian.” Premier Dexter said that after he entered provincial politics, Mr. Patterson would offer him advice and recommendations on how to deal with certain issues that would come up. “He was always very supportive and I always appreciated his advice. I want to express my sincere condolences to his family and friends during this difficult time. Arnie was a great person who will be missed by all who knew him.”last_img read more

Big renovations at Iqaluit airport – but who is working on the

first_imgKent Driscoll APTN National News$300-million is being spent renovating the airport in Iqaluit.Part of the deal is that the contractor was supposed to hire a certain percentage of Inuk workers.Is that happening?kdriscoll@aptn.caFollow @kentdriscolllast_img

NGT raps Delhi pollution control panel over air quality

first_imgNew Delhi: The National Green Tribunal has rapped the Delhi Pollution Control Committee (DPCC) over its failure to control air pollution in the national capital, saying it was avoiding its duties. A bench, headed by NGT Chairperson Justice Adarsh Kumar Goel, directed the Delhi chief secretary to look into the matter and take remedial measures about proper manning and effective functioning of the DPCC. “The tribunal may have to consider whether a statutory authority which is repeatedly failing to perform its duties should continue in position as one of the reasons which is contributing to unabated pollution in Delhi resulting in large scale deaths and diseases is the failure of statutory authorities to perform their duties. Also Read – After eight years, businessman arrested for kidnap & murder “In absence of responsiveness of the statutory authorities who have to carry out the orders of this tribunal, mere passing of paper orders will not advance the purpose for which this tribunal has been constituted under the law,” the bench said. It said that no officer or authority can be allowed to defeat law in the manner it is being done on regular basis by the DPCC. The tribunal said that in such a situation, option may also have to be explored for action under Section 18(2) of the Water (Prevention and Control of Pollution) Act, 1974, whereby the central government may handover the functions of defiant DPCC to the Central Pollution Control Board. Also Read – Two brothers held for snatchings “Before further action, we direct the Chief Secretary, Delhi to look into the matter and take remedial measures about proper manning and effective functioning of the DPCC. The DPCC may file a proper affidavit of the action taken in the matter before the next date,” the bench said. The tribunal was hearing a plea filed by city resident Rajesh Kumar alleging air pollution by a brake lining factory near Chajju Gate, Babarpur here. The NGT had earlier directed DPCC to furnish a factual and action taken report. “A report has been received vide e-mail dated March 29 to the effect that East Delhi Municipal Corporation has sealed the premises and the SHO (Welcome) will be keeping strict vigil. “The report does not show any steps for prosecution or recovery of compensation for damage to the environment on ‘Polluter Pays principle’,” the tribunal noted.last_img read more

Austrian FM Asks Turkish Anti-coup Demonstrators to Leave His Country

Casablanca – Austrian Minister of Foreign Affairs and Integration, Sebastian Kurz, has asked the Turkish community to leave Austria if they want to demonstrate in support of  the Turkish Recep Tayyip Erdo?an against the failed military coup.According to German daily Süddeutsche Zeitung, referenced in Al Jazeera, the Austrian government has summoned the Turkish ambassador to Vienna today to discuss the events and demonstrations organized by the pro-Erdo?an protestors in Austria.The minister stated in a television interview that the demonstrations in Austria in favor of the legitimate government are not at all worthwhile. He added that those who want to involve themselves in the internal affairs of Turkey are free to leave the country. Sebastian Kurz, who has been Austria’s Minister of Foreign Affairs and Integration since 2013, has distinguished himself as an ardent opponent of the security measures and the campaign of arrests of the coup plotters led by the Turkish government and Turkish Intelligence Services.Kurz has called upon the European leaders to stand firm against Turkey. He addressed a statement to the Turkish president claiming that they “will not allow a dictator state to emerge and grow in Turkey.”  The reaction of the Turkish government, Kurz continues, “is exaggerated and abusive … especially with respect  to reinstating the death penalty.”The same minister made a multiple-day visit to Egypt in May 2015 and met with the Egyptian president Abdelfattah Al-Sisi, who rose to power as a result of a coup against his predecessor, Mursi, who was sentenced to death by an Egyptian court.Edited by Elisabeth Myers read more

Morocco ‘Independent’ in Gulf Crisis, ‘Will Not Give Up’ on Allies:…

Rabat – Moroccan member of the House of Representatives Abdelatif Ouahbi has said that Morocco is not taking sides in the current crisis between the member states of the Gulf Cooperation Countries (GCC).In an opinion article sent to Morocco World News, the Authenticity and Modernity Party (PAM) MP writes that the Kingdom’s decision to send food supply to Qatar following the embargo imposed on it by other Gulf countries “should not be interpreted as taking sides with this or that party.”“Morocco affirmed its support for the Gulf’s security, but at the same time it did not cut ties with Qatar,” writes Ouahbi. “Everybody knew that Morocco is independent its decisions.” The MP goes on to say that Morocco’s policy is based on constantly striving to achieve international peace and security, adding that at the same time Morocco “will not give up on its allies and friends when there are disagreements between them.”“This position does not mean siding with or against anyone. It is for everybody’s benefit,” explains Ouahbi.Morocco’s choice for non-alignment in the Gulf crisis, Ouahbi suggests, is a wise decision taken by King Mohammed VI.He states that not taking sides in such a crisis is in the interest of Arab countries, explaining that the Kingdom’s position serves all at a time where conflicts and tensions between Arab states will expose them to more dangers and manipulations by regional and international powers.Earlier in June, Saudi Arabia, United Arab Emirates, and Bahrain, along with other allies from the Arab world and elsewhere, announced they would cut ties with Qatar for allegedly supporting terrorism and undermining the security of Gulf states.Qatar rejected the accusations which it called “unfounded.” Morocco abstained from joining in the general campaign against Qatar.King Mohammed VI, who leads the Kingdom’s diplomacy, has sent foreign minister Nasser Bourita to mediate between the Gulf leaders, with whom the king entertains very good relationships.Ouahbi stated that Morocco’s position is “for the benefit of all. It is for building the future because the region’s destiny lies in mutual cooperation, healthy dialogue, and having a long-term vision.” read more

Most important Buckeyes for 2014 – No 6 Jeff Heuerman

Then-junior tight end Jeff Heuerman (86) is tackled out of bounds during a game against Wisconsin Sept. 28 at Ohio Stadium. OSU won, 31-24.Credit: Lantern file photoAs we rapidly close in on the top five, The Lantern continues its countdown of the top 10 most important Buckeyes for the 2014 Ohio State football season.No. 6: Jeff Heuerman, senior tight endEvery season since Ben Hartsock’s 2003 departure, Buckeye fans across the state have been saying “this is the year” an OSU tight end becomes a key part of the passing game. Over time, after repeated underwhelming displays of production from the position, that statement has become a question.Is this the year?After years of failure, 2013 was a step in the right direction.In 2004 and 2005 it was Ryan Hamby’s chance. He’s best known for a dropped touchdown against Texas in 2005 that could have won the game. From 2006 to 2008 it was Rory Nicol’s chance, but he never managed more than 13 receptions.In 2009 Jake Ballard proved to be a solid player and had a key reception in OSU’s Rose Bowl win against Oregon, but he was not key to the offense.Jake Stoneburner broke through with 21 catches in 2010 and seven touchdowns in 2011, but he was more of an oversized receiver and still didn’t ooze production.After Stoneburner’s departure in 2012, this past season was finally Heuerman’s chance to shine.Heuerman tallied 26 receptions for 466 yards and four touchdowns –– easily the best tight end production OSU has had in a decade –– and proved to be a valuable safety valve for then-junior quarterback Braxton Miller.In 2014, Heuerman’s importance to the team will go well beyond his number of catches or his trips to the end zone. The most important thing will be when those catches occur.Miller is now a senior with another offseason under his belt, but he missed all of spring practice with a shoulder injury. He is expected to be set to go for the season opener, but that injury, and his injury in 2013 that caused then-senior quarterback Kenny Guiton to step in and attempt 109 passes, served as a wake-up call for coach Urban Meyer and his staff.For this team to be successful, Miller must be healthy, and Heuerman can do a lot to ensure he stays that way. Not only is he a strong blocker on the edge, Heuerman’s ability to bail Miller out in tough situations can prevent the signal caller from running as often as normal.Miller is certainly a runner first, but that might have to change of OSU is to be successful, and having the frame of Heuerman on the field gives him a near sure thing to check down to.Heuerman checks in at 6 feet, 5 inches and 255 pounds. He is an imposing presence on the field and the Buckeyes should hope to –– and expect to –– see a jump in his production for 2014.So is this the year? Does it really even matter?Heuerman put up great numbers last year, and as long as he continues his production and elevates his game, even more balls should be headed his way.OSU’s first game of the season is scheduled for Aug. 30 when the Buckeyes face Navy in Baltimore, Md. read more

iPad Stealing Market Share From Kindle Study

first_imgApple’s iPad has been stealing eBook reader market share away from Amazon’s Kindle since August, according to a new study by ChangeWave. Between the beginning of August and November 8th, the Kindle lost 15 of the market, dropping down to 47 percent. Apple, meanwhile, rose 16 percent up to 32 percent of the market. Sony’s reader is in a distant third at five percent, with Barnes and Noble’s Nook on its tale at four percent.More interesting tidbits from the study: AdChoices广告75 percent of iPad and 54 percent of Kindle owners are “very satisfied.”93 Percent of Kindle and 76 percent of iPad owners use their device to read books.Users are five times more likely to read newspapers on the iPad than the Kindle. Five percent of those surveyed are “very likely” to buy an eReader in the next 90 days.Of those planning to buy one, 42 percent are likely to buy an iPad, with 33 percent likely to buy a Kindle.last_img read more

Boat catches fire at Miami Beach Marina

first_imgMIAMI BEACH, FLA. (WSVN) – An unoccupied boat at a marina located south of Fifth Street in South Beach caught on fire, Saturday afternoon.Miami Beach Fire Rescue and Miami-Dade Fire Rescue responded to the burning vessel at the Miami Beach Marina, located at 300 Alton Road.A 7News viewer sent in video showing heavy smoke as the blaze burned on boardNo one was injured.The cause of the fire remains under investigation.Remember, if you see news happening and can do so safely, take a picture or shoot video and send it to: senditto7@wsvn.com.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.last_img read more

Cover Critique Time Outs DuctTaped Sex

first_imgTime Out New York followed up its “sex issue” (“How Not to Promote Your Magazine’s Special Issue”) with the anti-sex, err, anti-Sex and the City issue. The cover features a photo illustration of the show’s stars with their mouths duct-taped shut. It’s an effort to combat the relentless hype the HBO-hit-turned-movie has garnered (see Entertainment Weekly’s latest cover, for starters). It also serves as a thinly-veiled shot to its bigger, more established (and, frankly, better-designed) rival, New York magazine, which last week plopped Sex star Sarah Jessica Parker on its cover, declaring “Sex is Back”—as if it had never left.NAME: Tim O’BrienTITLE: Illustrator, Rolling StoneCRITIQUE: I subscribe to Time Out. They often have clever concepts on their covers. For me, a photoshop gag has to be well executed to work. I get that this movie is being talked about way too much, but duct tape over a woman’s mouth, anyone’s mouth is always sick. The trick can work visually, however, if the lighting on the tape matches the lighting on the women. In each, the model who posed with tape on their face for the photographer had one light source from the side and merely turned the head to match the head positions. The lighting on the photo of the Sex ladies is controlled and flat to minimize father time. The mix of both makes the tape too dark on the shadow side but works best on Cynthia Nixon, I guess. I would also have had the headline, “NO MORE SEX!” If I were in on the concept meeting, I might have pitched a photo of a torn and weathered poster on a wall in Manhattan with other images beneath it. New Yorkers show how they’ve move on in the small editorials written on posters in the subways. Perhaps it’s too subtle though. Here [right] is how it might look. After doing it, I might like their cover more. Ha!NAME: Dan TrombettoTITLE: art director, FOLIO:CRITIQUE: I was hesitant to comment on this one, because I felt my opinions might be swayed by the fact that I detest the show and its characters and I cringe whenever I see the trailers for the movie. So because of my feelings toward Sex, this image and concept immediately brings me some perverse sense of joy. Sure, the cover subject with a duct-taped mouth has been done a few times before—but this image does convey exactly how I feel about the franchise at this point. It’s probably safe to say that much of their target audience (New Yorkers) share these sentiments as well. And while I don’t think they were really aiming for a design award with this cover, it still probably could have benefited from a smaller color range. Maybe it’s the reds that aren’t mixing too well with the cooler pinks, lavenders, blues … Color clashing aside, this cover still makes me happy. NAME: Marco TurelliTITLE: Art Director, Wine Enthusiast magazineCRITIQUE: Luckily for TONY, they don’t have to rely on newsstand sales. I think that it is an adequate attempt at not much of a rebuttal to NY Magazine’s coverage. I’m sure that I could enjoy NYC Carrie-free 1965 times between Ave A and B alone, so I don’t think that the cover line really sells me on much. I’m sure readers in Jersey and Queens will be jumping out of their socks when they see this issue. Color palette is horrible. Off the top of my head I’d rather see a pile of designer shoes in a dumpster with the “no sex” cover line. Better than what looks to be stock shots of somewhat asexual, past-their-prime women. (Maybe it does work?) I’d give it two out of five stars, I guess. What do you think? Leave your own critiques in the comments section below … PAST FOLIO: COVER CRITIQUES:Rolling Stone’s Barack Obama EndorsementVogue’s Lebron and GiseleNew York’s Spitzer Coverlast_img read more